Antidepressant effects of selective slow wave sleep deprivation in major depression: a high-density EEG investigation.

Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder.

The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has rapid antidepressant effects in treatment-resistant major depressive disorder (MDD). In rats, ketamine selectively increased electroencephalogram (EEG) slow wave activity (SWA) during non-rapid eye movement (REM) sleep and altered central brain-derived neurotrophic factor (BDNF) expression. Taken together, these findings suggest t...

EEG arousals in normal sleep: variations induced by total and selective slow-wave sleep deprivation.

STUDY OBJECTIVES Aim of the present study was to assess changes in arousal rates after selective slow-wave (SWS) and total sleep deprivations. DESIGN Two-way mixed design comparing the arousal index (Al), as expressed by the number of EEG arousals divided by sleep duration, in totally or selectively sleep deprived subjects. SETTING Sleep laboratory. PATIENTS OR PARTICIPANTS Nineteen norma...

Reduction in delta activity predicted improved negative affect in Major Depressive Disorder.

While prior research has demonstrated a paradoxical antidepressant effect of slow-wave disruption (SWD), the specific dimensions of depression affected is still unclear. The current study aimed to extend this research by utilizing a dimensional approach in examining the antidepressant effects of SWD. Of particular interest is the affective dimension, as negative affect in depression is arguably...

University of Groningen Quantitative Analysis of the Effects of Slow Wave Sleep Deprivation During the First 3 h of Sleep on Subsequent EEG Power Density

Sleep Microarchitecture in Depression: Association with Response to Bupropion Treatment

There are a number of reasons to consider the regulation of sleep as an essential component for understanding the pathophysiology and treatment of depression (1). For instance, sleep complaints are commonly associated with depression and form an essential criterion of the diagnosis (2). Persistent sleep disturbances increase the vulnerability to depression (3,4). EEG sleep changes associated wi...